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药剂学

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张默博士-副教授

发布时间:2019-10-30   浏览次数:0

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张默,副教授,中共党员,硕士生导师。2022年6月毕业于北京理工大学,并于同年9月入职5848vip威尼斯电子游戏。无机物化教研室教师,主讲本科生物理化学课程。科研方向为药物创新给药体系的构建和纳米材料的生物应用研究。主持国家自然科学基金青年基金1项,中国博士后基金2项,河北省高等学校科学技术青年拔尖项目1项,河北省博士后择优资助项目1项和5848vip威尼斯电子游戏春雨计划优秀青年基金1项。目前以第一作者、通讯作者发表研究论文20余篇。

主持项目情况:

1. 国家自然科学基金青年基金,多钼氧酸盐@共价有机框架复合物的构筑及抗肿瘤研究,2024/01-2026/12,20301060,30万。

2. 中国博士后科学基金特别资助,多酸基羟基磷灰石/壳聚糖复合材料多模式联合促进骨折愈合及机制研究,2022/12-2024/12,2023TQ0103,18万。

3. 中国博士后科学基金面上项目,以激活BMP/Samd信号通路为靶点的多酸基水凝胶复合材料促进骨折愈合研究,2022/12-2024/12,2023M730914,8万。

4. 河北省高等学校科学技术青年拔尖项目,以激活细胞焦亡通路为靶点的多酸基纳米胶束构建及抗肿瘤研究,2024/01-2026/12,BJK2024190,10万。

5. 5848vip威尼斯电子游戏春雨计划优秀青年基金,以激活细胞凋亡路通为靶点构建多酸基复合纳米药物用于胰腺癌精准治疗及机制研究,2023/01-2025/12,CYYQ2023004,30万。

发表论文情况:

1. Mo Zhang, Fan Xu, Jingcheng Cao, Qingqing Dou, Juan Wang, Jing Wang, Lei Yang*, Wei Chen*. Research advances of nanomaterials for the acceleration of fracture healing. Bioact. Mater. 2024, 31, 368-394.

2. Mo Zhang#, Zheng Li#, Yeqin Feng, Xing Xin, Guo-Yu Yang* and Hongjin Lv*. Highly selective hydrogenolysis of lignin β-O-4 models by a coupled polyoxometalate/CdS photocatalytic system. Green Chem. 2023, 25, 10091-10100.

3. Mi Wang#, Mo Zhang#, Xiaoxiao Hu, Wenli Wang, Yao Zhang, Lina Zhang, Jing Wang*, Lipid-functionalized gold nanorods with plug-to-direct mitochondria targeting ligand for synergetic photothermal-chemotherapy of tumor therapy. Eur. J. Pharm. Biopharm. 2023, 185, 71-81.

4. Mo Zhang, Xing Xin, Yeqin Feng, Junhao Zhang, Hongjin Lv*, and Guo-Yu Yang*. Coupling Ni-substituted polyoxometalate catalysts with water-soluble CdSe quantum dots for ultraefficient photogeneration of hydrogen under visible light. Appl. Catal. B: Environ. 2021, 333, 120893.

5. Mo Zhang, Huijie Li, Junhao Zhang, Hongjin Lv*, Guo‐Yu Yang*. Research advances of light‐driven hydrogen evolution using polyoxometalate‐based catalysts. Chin. J. Catal. 2021, 42, 855-871.

6. Mo Zhang, Wang Sun, Hongjin Lv*, and Zhan-Hui Zhang*. Syntheses and applications of perovskite-based photocatalysts in light-driven organic reactions. Curr. Opin. Green. Sustain. Chem. 2021, 27, 100390.

7. Mo Zhang, Zheng Li, Xing Xin, Junhao Zhang, Yeqin Feng, and Hongjin Lv*. Selective valorization of 5 hydroxymethylfurfural to 2,5-diformylfuran using atmospheric O2 and MAPbBr3 perovskite under visible light. ACS Catal. 2020, 10, 14793-14800.

8. Mo Zhang, Meng-Nan Chen, and Zhan-Hui Zhang*. Visible light-initiated catalyst-free one-pot, multicomponent construction of 5-substituted indole chromeno[2,3-b]pyridines. Adv. Synth. Catal. 2019, 361, 5182-5190.

9. Mo Zhang, Meng-Nan Chen, Jiao-Mian Li, Nan Liu, and Zhan-Hui Zhang*. Visible-light-initiated one-pot, three-component synthesis of 2-amino-4H-pyran-3,5-dicarbonitrile derivatives. ACS Comb. Sci. 2019, 21, 685-691.

10. Mo Zhang, Qiu-Yang Fu, Ge Gao, He-Ye He, Ying Zhang, Yin-Su Wu, and Zhan-Hui Zhang*. Catalyst-Free, visible-light promoted one-pot synthesis of spirooxindole-pyran derivatives in aqueous ethyl lactate. ACS Sustain Chem. Eng. 2017, 5, 6175-6182.

11. Mo Zhang, Yi Han, Jia-Liang Niu, and Zhan-Hui Zhang*. A general and practical approach for the synthesis of 1,2,4-trioxanes catalyzed by silica-ferric chloride. Adv. Synth. Catal. 2017, 359, 3618-3625.

12. Mo Zhang, Yu-Heng Liu, Ze-Ren Shang, Hai-Chuan Hu, Zhan-Hui Zhang*. Supported molybdenum on graphene oxide/Fe3O4: An efficient, magnetically separable catalyst for one-pot construction of spiro-oxindole dihydropyridines in deep eutectic solvent under microwave irradiation. Catal. Commun. 2017, 88, 39-44.

13. Mo Zhang, Ze-Ren Shang, Xiao-Tang Li, Jia-Nan Zhang, Yong Wang, Kang Li, Yang-Yang Li, Zhan-Hui Zhang*. Simple and efficient approach for synthesis of hydrazones from carbonyl compounds and hydrazides catalyzed by meglumine. Synth. Commun. 2017, 47, 178-187.

14. Mo Zhang, Jun Lu, Jia-Nan Zhang, Zhan-Hui Zhang*. Magnetic carbon nanotube supported Cu (CoFe2O4/CNT-Cu) catalyst: A sustainable catalyst for the synthesis of 3-nitro-2-arylimidazo[1,2-a]pyridines. Catal. Commun. 2016, 78, 26-32.

15. Mo Zhang, Peng Liu, Yu-Heng Liu, Ze-Ren Shang, Hai-Chuan Hu, and Zhan-Hui Zhang*. Magnetically separable graphene oxide anchored sulfonic acid: a novel, highly efficient and recyclable catalyst for one-pot synthesis of 3,6-di(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles in deep eutectic solvent under microwave irradiation. RSC Adv. 2016, 6, 106160-106170.